中国药物滥用防治杂志

目的：探讨SSRIs单药治疗与SSRIs联合认知行为疗法（CBT）对青少年抑郁症康复的影响。方法：选取2024年4月—2025年4月我院收治的130例青少年抑郁症患者，随机分为对照组（SSRIs单药治疗）和观察组（SSRIs联合CBT治疗）。治疗8周后，比较两组患者的汉密尔顿抑郁量表（HAMD）评分、临床疗效总评量表（CGI）评分、药物依从性评分以及药物滥用倾向评估结果以及社会功能恢复情况。结果：治疗后，观察组HAMD评分、CGI评分、药物滥用风险评分均低于对照组，药物依从性评分、社会功能评分高于对照组（P<0.05）；且治疗8周后，观察组血清5-HT水平高于对照组，皮质醇水平低于对照组（P<0.05）。结论：SSRIs联合CBT治疗在青少年抑郁症康复中优于SSRIs单药治疗，能够提高药物依从性，降低药物滥用倾向，并促进社会功能恢复。

Objective: To explore the effect of SSRIs monotherapy and SSRIs combined with cognitive behavioral therapy(CBT) on the rehabilitation of adolescent depression. Methods: A total of 130 patients with adolescent depression admitted to our hospital from April 2024 to April 2025 were randomly divided into control group(SSRIs monotherapy) and observation group(SSRIs combined with CBT). After 8 weeks of treatment, the Hamilton Depression Scale(HAMD) score, Clinical Global Impression(CGI) score, drug compliance score, drug abuse tendency assessment results and social function recovery were compared between the two groups. Results: After treatment, the HAMD score, CGI score and drug abuse risk score of the observation group were lower than those of the control group, and the drug compliance score and social function score were higher than those of the control group(P<0.05). After 8 weeks of treatment, the serum 5-HT level in the observation group was higher than that in the control group, and the cortisol level was lower than that in the control group(P<0.05). Conclusion: SSRIs combined with CBT is superior to SSRIs monotherapy in the rehabilitation of adolescent depression, which can improve drug compliance, reduce drug abuse tendency and promote social function recovery.