中国药物滥用防治杂志

目的：探究不同用药管理模式对老年2型糖尿病患者多重用药安全性与治疗效果的影响，为临床合理选择用药管理模式提供参考依据。方法：选取南阳市宛城区第一人民医院2023年5月—2024年5月收治的88例老年2型糖尿病多重用药患者作为研究对象，按照随机数字表法分为对照组和观察组，每组44例。对照组采用常规用药管理模式，观察组采用精细化用药管理模式。比较两组用药安全性（不良反应发生率）和治疗效果（血糖指标、血脂指标、生活质量评分等）。结果：观察组不良反应发生率低于对照组（P<0.05）；观察组管理后空腹血糖、餐后2小时血糖、糖化血红蛋白、总胆固醇、甘油三酯水平均低于对照组，高密度脂蛋白胆固醇水平高于对照组（P<0.05）；观察组管理后生活质量评分高于对照组，用药依从性好占比高于对照组（P<0.05）。结论：精细化用药管理模式可提高老年2型糖尿病患者多重用药的安全性，改善治疗效果，提升患者生活质量，值得临床应用。

Objective: To explore the effects of different medication management modes on the safety and therapeutic effect of polypharmacy in elderly patients with type 2 diabetes mellitus, and to provide reference for clinical rational selection of medication management mode. Methods: From May 2023 to May 2024, 88 elderly patients with type 2 diabetes mellitus treated with multiple drugs in the Wancheng District First People's Hospital were selected as the research objects. According to the random number table method, they were divided into control group and observation group, with 44 patients in each group. The control group was treated with routine medication management mode, and the observation group was treated with refined medication management mode. The safety(incidence of adverse reactions) and therapeutic effect(blood glucose index, blood lipid index, quality of life score, etc.) were compared between the two groups. Results: The incidence of adverse reactions in the observation group was lower than that in the control group(P<0.05). The levels of fasting blood glucose, 2-hour postprandial blood glucose, glycosylated hemoglobin, total cholesterol and triglyceride in the observation group were lower than those in the control group, and the level of high-density lipoprotein cholesterol was higher than that in the control group(P<0.05). The quality of life score of the observation group after management was higher than that of the control group, and the proportion of good medication compliance was higher than that of the control group(P<0.05). Conclusion: The refined medication management model can improve the safety of multiple medications in elderly patients with type 2 diabetes mellitus, improve the treatment effect, and improve the quality of life of patients, which is worthy of clinical application.