中国药物滥用防治杂志

目的：分析针对性护理应用在早期糖尿病肾病患者药物治疗期间的效果。方法：选取2022年1月—2025年1月我院早期糖尿病肾病患者78例，随机分为观察组和对照组，每组39例。对照组予以常规护理，观察组予以针对性护理。对比两组症状缓解时间（蛋白尿、慢性高血糖、厌食）、血糖水平[空腹血糖（fasting blood glucose,FBG）、餐后2h血糖（postprandial blood glucose at 2 hours,2hPG）]、血脂指标[总胆固醇（total cholesterol,TC）、甘油三酯（triglyceride,TG）]、肾功能[尿素氮（urea nitrogen,BUN）、血肌酐（blood creatinine,Scr）、尿蛋白]、心理状态[焦虑自评量表（Self-Rating Anxiety Scale,SAS）评分、抑郁自评量表（Self-Rating Depression,SDS）评分]及生活质量量表（Quality of Life Scale 36,SF-36）评分。结果：观察组干预后蛋白尿、慢性高血糖、厌食缓解时间较对照组短，FBG、2hPG、TC、TG、BUN、Scr、尿蛋白水平较对照组低，SDS评分、SAS评分较对照组低，而生理功能、社会功能、躯体功能、精神健康评分较对照组高（P<0.05）。结论：在早期糖尿病肾病应用汀类药物治疗中予以针对性护理可加快症状改善，能改善血脂代谢和肾功能，并能减轻焦虑、抑郁等负性情绪，提高生活质量。

Objective: To analyze the effect of targeted nursing on patients with early diabetic nephropathy during drug treatment period. Methods: A total of 78 patients with early diabetic nephropathy in our hospital from January 2022 to January 2025 were randomly divided into observation group and control group, with 39 patients in each group. The control group was given routine nursing, and the observation group was given targeted nursing. The symptom relief time(proteinuria, chronic hyperglycemia, anorexia), blood glucose level [fasting blood glucose(FBG), Postprandial blood glucose at 2 hours(2 hPG)], blood lipid index [total cholesterol(TC), triglyceride(TG)], renal function [urea nitrogen(BUN), blood creatinine(Scr), urine protein], psychological state [Selfrating Anxiety Scale(SDS) score, self-rating Depression Scale(SAS) score] and quality of life scale(SF-36) score were compared between the two groups. Results: The remission time of proteinuria, chronic hyperglycemia and anorexia in the observation group was shorter than that in the control group, the levels of FBG, 2 hPG, TC, TG, BUN, Scr and urinary protein in the observation group were lower than those in the control group, the scores of SDS and SAS in the observation group were lower than those in the control group, while the scores of physiological function, social function, physical function and mental health in the observation group were higher than those in the control group(P<0.05). Conclusion: Targeted nursing in the treatment of early diabetic nephropathy with statins can accelerate the improvement of symptoms, improve blood lipid metabolism and renal function, reduce negative emotions such as anxiety and depression, and improve the quality of life.